Puppy Vaccination Schedule: 5-Way + Corona Guide
By UPCO Pet Supplies | Small Business Pet Shop in St. Joseph MO | Published: 2026-10-19
Category: How-to Guides
Learn the recommended timeline for your puppy's 5-Way + Corona vaccine, including what it covers and when to give each dose.
Quick Answer
Puppies need a series of 5-Way + Corona (DAPPV+CV) vaccines starting at 6-8 weeks old, with boosters every 3-4 weeks until 16-18 weeks of age, then a final booster at one year.
What the 5-Way + Corona Vaccine Covers
The 5-Way + Corona vaccine protects against six diseases: canine distemper virus, adenovirus type 1 (hepatitis), adenovirus type 2 (respiratory disease), canine parainfluenza virus, canine parvovirus, and coronavirus. The "5-Way" refers to the core five viruses (distemper, adenovirus 1&2, parainfluenza, parvovirus), and the "+ Corona" adds protection against canine coronavirus, which causes mild to moderate diarrhea in puppies.
A common misconception is that canine coronavirus is the same as the human COVID-19 virus—it is not. This vaccine targets a different, species-specific virus that affects the gastrointestinal tract.
Why Puppies Need a Series, Not a Single Shot
Puppies receive temporary immunity from their mother's milk (maternal antibodies), but these antibodies can also block the vaccine from working. Since maternal antibody levels vary by puppy, a single dose at any age may not provide full protection. A series of vaccines given at 3-4 week intervals ensures that once maternal antibodies fade, the puppy's immune system is ready to respond.
This is why sticking to the schedule is critical—delaying a booster can leave a gap in protection.
Step-by-Step Puppy Vaccination Schedule for 5-Way + Corona
- First Dose: 6–8 Weeks Old: Give the first DAPPV+CV vaccine at your puppy's earliest veterinary visit, typically at 6 to 8 weeks of age. This starts the immune response but is often blocked by maternal antibodies. Do not skip this dose even if you think it might not fully work—it primes the system.
- Second Dose: 10–12 Weeks Old: Administer the second dose 3 to 4 weeks after the first. By this age, maternal antibodies are declining, and the puppy's immune system begins to mount its own protection. If you miss this window, give the booster as soon as possible—do not restart the series.
- Third Dose: 14–16 Weeks Old: Give the third dose at 14 to 16 weeks. This is the most important dose because maternal antibodies are now low enough that the vaccine reliably triggers long-term immunity. A common mistake is stopping after two doses—three are needed for full protection.
- Optional Fourth Dose: 16–18 Weeks Old: Some protocols recommend a fourth dose at 16 to 18 weeks, especially for high-risk breeds or environments (e.g., kennels, dog parks). Check with your veterinarian. Not all puppies need a fourth dose; follow your vet's risk assessment.
- One-Year Booster: Give a final booster at 12 months of age. This dose completes the initial puppy series and transitions your dog to the adult vaccination schedule (every 1–3 years depending on the vaccine and local laws). Mark your calendar—this is easy to forget once your puppy seems fully grown.
Product Facts
- NOBIVAC Canine 1-DAPPV+CV Dog Vaccine 25×1 Dose: NOBIVAC Canine 1-DAPPV+CV Dog Vaccine 25×1 Dose is recommended for healthy dogs to aid in preventing disease caused by canine distemper virus, adenovirus type 1 (hepatitis), adenovirus type 2 (respiratory disease), canine parainfluenza virus, canine parvovirus, and coronavirus. This single product covers all six viruses in the 5-Way + Corona schedule, so you only need one vial per vaccination session for your puppy series.
NOBIVAC Canine 1-DAPPV+CV Dog Vaccine 25×1 Dose
