UPCO Pet Supplies | Small Business Pet Shop in St. Joseph MO

PetAg Esbilac Puppy Milk Replacer Powder 5 lb

Give newborn puppies the best start with complete, balanced nutrition. Esbilac® supports growth, digestion, and immune health — ideal for orphaned, rejected, or supplemental feeding. Mixes easily. Trusted by breeders & rescues.

PetAg Esbilac Puppy Milk Replacer Powder 5 lb - Main image
$100.97 $152.99 In stock

Category: Puppy Milk Replacer

Esbilac® Puppy Milk Replacer Powder — Complete, Balanced Nutrition for Newborn & Orphaned Puppies

Esbilac® is the trusted milk replacer for puppies who need a nutritious start — whether orphaned, rejected, supplementing a large litter, or just not getting enough from mom. Formulated to closely match the mother’s milk profile, Esbilac provides highly digestible proteins, essential fats, vitamins, and minerals to support healthy growth, brain development, and a strong immune system.

  • Complete nutrition for puppies from birth to 6 weeks
  • Highly digestible formula gentle on tiny tummies
  • Mixes smooth — ideal for bottle, syringe, or tube feeding
  • Great value 5 lb size for breeders, rescues, and foster programs

Why Choose Esbilac®?

  • Mother’s-milk inspired: Balanced protein, fat, and carbohydrate profile to support steady growth.
  • Brain & vision support: Includes key fatty acids (e.g., DHA sources) important for early development.
  • Trusted by pros: Widely used by breeders, shelters, and veterinary teams.
  • Flexible use: For orphaned pups, supplemental feeding in large litters, or as a weaning transition.

Good to know: Esbilac can also be used as a post-surgery or convalescent nutritional boost for puppies under veterinary guidance.


How to Mix

Standard mix: Combine 1 part powder with 2 parts warm water. Stir or shake until fully dissolved and smooth. Prepare small batches as needed.

  • Serve warm (body temperature). Do not microwave mixed formula; instead warm the bottle in a warm water bath.
  • Refrigerate unused mixed formula and use within 24 hours. Keep the powder container tightly sealed and store in a cool, dry place.

Feeding Frequency & Amount (Guideline)

Newborn puppies typically need small, frequent feedings. The amounts below are general guidelines only — always monitor body condition and consult your veterinarian for specific needs.

Puppy Weight Approx. Age Per-Feeding Volume* Feedings / 24 hrs
4–8 oz (115–230 g) 0–1 week 5–10 mL 6–8x
9–16 oz (255–455 g) 1–2 weeks 10–20 mL 6–8x
17–32 oz (480–910 g) 2–3 weeks 15–30 mL 5–6x
33–64 oz (0.94–1.8 kg) 3–4 weeks 25–50 mL 4–5x
> 64 oz (>1.8 kg) 4–6 weeks 40–60+ mL 3–4x

*Adjust volume to puppy size and appetite. Stomach capacity is small — multiple small feedings are safer than large ones.

Weaning tip (3–6 weeks): Begin offering a shallow dish of mixed formula; gradually blend with high-quality puppy food to create a gruel. Increase food and decrease formula over several days as pups accept solids.


Frequently Asked Questions

Q: From what age can I use Esbilac?
A: From birth up to about 6 weeks, or as directed by your veterinarian for supplemental feeding and weaning support.

Q: What’s the correct mixing ratio?
A: Mix 1 part powder with 2 parts warm water and blend until smooth.

Q: Can I microwave the formula?
A: No. Microwaving can create hot spots. Warm the prepared bottle in a warm water bath and test on your wrist before feeding.

Q: How long can mixed formula be stored?
A: Refrigerate and use within 24 hours. Discard any leftover in the bottle after each feeding for hygiene.

Q: Bottle, syringe, or tube?
A: Bottle feeding is most common. Syringe feeding can help with very weak pups; tube feeding should be done only with training or veterinary guidance.

Q: My puppy has loose stool — what should I do?
A: First, ensure you’re mixing correctly and not over-feeding. Keep pups warm and dry. If diarrhea persists, contact your veterinarian promptly.

Q: When should I begin weaning?
A: Many pups start exploring gruel around 3–4 weeks. Increase solids gradually while reducing formula.


Quality & Trust

  • Widely trusted by breeders, rescues, and veterinary professionals
  • Consistent, reliable mixing for smooth bottle feeding
  • UPCO support: Real people, real help — call or email us if you need feeding guidance

Feeding newborns is delicate. Always follow label directions and seek veterinary advice for weak, ill, or dehydrated puppies.


Complete Your Feeding Kit

  • Puppy nursing bottles & nipple kits
  • Feeding syringes (for supplemental feeding)
  • Whelping & warming pads
  • Bottle brushes & cleaning supplies
  • Weaning foods & digestive support

Compare at a Glance

Feature Esbilac® (Puppies) Zoologic Milk Matrix 33/40.5 Generic Milk Replacer
Intended Use Puppies (birth–6 wks), supplement & weaning Puppies & select species (per label) General
Digestibility High High Varies
Fatty Acids for Brain Development Included Included Often limited
Breeder/Rescue Friendly Sizes Yes (incl. 5 lb) Yes Varies

Always select a formula labeled for puppies and follow the manufacturer’s feeding directions.


Questions? We’re Here to Help.

Our team has helped thousands of caregivers get newborns off to a great start. Contact us for quick, friendly support.

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United States · Return window (days after delivery): 30. Return method: By mail. Return postage: Seller pays.

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Customer Reviews (5.0 / 5 · 2 reviews)

Ellie P. ★★★★★

My foster pup was barely gaining weight until I switched to this powder, and within a week she was noticeably rounder and more energetic. The scoop mixes smoothly with warm water, and the 5 lb bag lasted us almost a month with twice-daily feedings.

Ava K. ★★★★★

We had a sudden litter and this powder mixed up smoothly without clumps, which was a huge relief during late-night feedings. Our runt puppy is finally gaining weight steadily after just a few days.